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Editor-In-Chief:C. Michael Gibson, M.S., M.D.[1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D.[2];Aparna Vuppala, M.B.B.S.[3]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Tirofiban is a platelet aggregation inhibitor that is FDA approved for the treatment of reduce the rate of thrombotic cardiovascular events. Common adverse reactions include bradyarrhythmia, bleeding, pain in pelvis.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Reduction the rate of thrombotic cardiovascular events

• Dosing information

• 25 mcg/kg IV over 3 minutes and then 0.15 mcg/kg/min (or 0.075 mcg/kg/min for patients with serum creatinine ≤60 mL/min), for up to 18 hours. This is not the regimen that was used in studies that established effectiveness of Tirofiban .
• The instructions by weight and creatinine clearance are tabulated in Table 1.

• Important Administration Instructions

• To open the container, first tear off its foil overpouch. The plastic may be somewhat opaque because of moisture absorption during sterilization; the opacity will diminish gradually. Check for leaks by squeezing the inner bag firmly; if any leaks are found or sterility is suspect then the solution should be discarded. Do not use unless the solution is clear and the seal is intact. Suspend the container from its eyelet support, remove the plastic protector from the outlet port, and attach a conventional administration set.
• You may administer Tirofiban in the same intravenous line as atropine sulfate, dobutamine, dopamine, epinephrine hydrochloride (HCl), famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride, and propranolol HCl. :* :* Do not administer Tirofiban through the same IV line as diazepam.
• Do not add other drugs or remove solution directly from the bag with a syringe.
• Do not use plastic containers in series connections; such use can result in air embolism by drawing air from the first container if it is empty of solution.
• Discard any unused portion left in the bag.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Tirofiban sandbox in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Tirofiban sandbox in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Safety and effectiveness in pediatric patients have not been established.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Tirofiban sandbox in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Tirofiban sandbox in pediatric patients.

Contraindications

• Severe hypersensitivity reaction to Tirofiban (i.e., anaphylactic reactions) .
• A history of thrombocytopenia following prior exposure to Tirofiban .
• Active internal bleeding or a history of bleeding diathesis, major surgical procedure or severe physical trauma within the previous month

Warnings

General Risk of Bleeding

Bleeding is the most common complication encountered during therapy with Tirofiban. Most bleeding associated with Tirofiban occurs at the arterial access site for cardiac catheterization. Minimize the use of traumatic or potentially traumatic procedures such arterial and venous punctures, intramuscular injections, nasotracheal intubation, etc. Fatal bleeding events have been reported .

Concomitant use offibrinolytics, oral anticoagulants and antiplatelet drugs increases the risk of bleeding.

Thrombocytopenia

Profound thrombocytopenia has been reported with Tirofiban. Monitor platelet counts beginning about 6 hours after treatment initiation and daily thereafter. If the platelet count decreases to less than 90,000/mm3, monitor platelet counts to exclude pseudothrombocytopenia. If thrombocytopenia is confirmed, discontinue Tirofiban and heparin. Previous exposure to a glycoprotein (GP) IIb/IIIa receptor antagonist may increase the risk of developing thrombocytopenia .

Adverse Reactions

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In the PRISM (Platelet Receptor Inhibition for Ischemic Syndrome Management), PRISM-PLUS (Platelet Receptor Inhibition for Ischemic Syndrome Management — Patients Limited by Unstable Signs and Symptoms) and RESTORE (Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis) trials, 1946 patients received Tirofiban in combination with heparin and 2002 patients received Tirofiban alone for about 3 days. Forty-three percent of the population was greater than 65 years of age and approximately 30% of patients were female. In clinical studies with the recommended regimen (25 mcg/kg bolus followed by a 0.15 mcg/kg/min maintenance infusion), Tirofiban was administered in combination with aspirin, clopidogrel and heparin or bivalirudin to over 8000 patients for typically ≤24 hours. Approximately 30% of the population was >65 years of age and approximately 25% were female.

Bleeding

PRISM-PLUS Regimen

The incidences of major and minor bleeding using the TIMI criteria in the PRISM-PLUS study are shown below.

Postmarketing Experience

The following additional adverse reactions have been identified during post-approval use of Tirofiban. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to the drug exposure.

Hypersensitivity: Severe allergic reactions including anaphylactic reactions have occurred during the first day of Tirofiban infusion, during initial treatment, and during readministration of Tirofiban. Some cases have been associated with severe thrombocytopenia (platelet counts less than 10,000/mm3). No information is available on the formation of antibodies to tirofiban.

Drug Interactions

Use ofthrombolytics, anticoagulants, and other antiplatelet agents.

Coadministration of antiplatelet agents, thrombolytics, heparin, and aspirin increases the risk of bleeding.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): BThere are no adequate and well-controlled studies in pregnant women. Tirofiban has been shown to cross the placenta in pregnant rats and rabbits. Studies with tirofiban HCl at intravenous doses up to 5 mg/kg/day (about 5 and 13 times the maximum recommended daily human dose for rat and rabbit, respectively, when compared on a body surface area basis) have revealed no harm to the fetus.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Tirofiban in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Tirofiban during labor and delivery.

Nursing Mothers

It is not known whether tirofiban is excreted in human milk. However, significant levels of tirofiban were shown to be present in rat milk. Because many drugs are excreted in human milk, and because of the potential for adverse effects on the nursing infant, discontinue nursing or discontinue Tirofiban.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatic Use

• 25 mcg/kg IV over 3 minutes and then 0.15 mcg/kg/min (or 0.075 mcg/kg/min for patients with serum creatinine ≤60 mL/min), for up to 18 hours. This is not the regimen that was used in studies that established effectiveness of Tirofiban .
• The instructions by weight and creatinine clearance are tabulated in Table 1.

• Important Administration Instructions

• To open the container, first tear off its foil overpouch. The plastic may be somewhat opaque because of moisture absorption during sterilization; the opacity will diminish gradually. Check for leaks by squeezing the inner bag firmly; if any leaks are found or sterility is suspect then the solution should be discarded. Do not use unless the solution is clear and the seal is intact. Suspend the container from its eyelet support, remove the plastic protector from the outlet port, and attach a conventional administration set.
• You may administer Tirofiban in the same intravenous line as atropine sulfate, dobutamine, dopamine, epinephrine hydrochloride (HCl), famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride, and propranolol HCl. :* :* Do not administer Tirofiban through the same IV line as diazepam.
• Do not add other drugs or remove solution directly from the bag with a syringe.
• Do not use plastic containers in series connections; such use can result in air embolism by drawing air from the first container if it is empty of solution.
• Discard any unused portion left in the bag.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Tirofiban sandbox in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Tirofiban sandbox in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Safety and effectiveness in pediatric patients have not been established.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Tirofiban sandbox in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Tirofiban sandbox in pediatric patients.

Contraindications

• Severe hypersensitivity reaction to Tirofiban (i.e., anaphylactic reactions) .
• A history of thrombocytopenia following prior exposure to Tirofiban .
• Active internal bleeding or a history of bleeding diathesis, major surgical procedure or severe physical trauma within the previous month

Warnings

General Risk of Bleeding

Bleeding is the most common complication encountered during therapy with Tirofiban. Most bleeding associated with Tirofiban occurs at the arterial access site for cardiac catheterization. Minimize the use of traumatic or potentially traumatic procedures such arterial and venous punctures, intramuscular injections, nasotracheal intubation, etc. Fatal bleeding events have been reported .

Concomitant use offibrinolytics, oral anticoagulants and antiplatelet drugs increases the risk of bleeding.

Thrombocytopenia

Profound thrombocytopenia has been reported with Tirofiban. Monitor platelet counts beginning about 6 hours after treatment initiation and daily thereafter. If the platelet count decreases to less than 90,000/mm3, monitor platelet counts to exclude pseudothrombocytopenia. If thrombocytopenia is confirmed, discontinue Tirofiban and heparin. Previous exposure to a glycoprotein (GP) IIb/IIIa receptor antagonist may increase the risk of developing thrombocytopenia .

Adverse Reactions

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In the PRISM (Platelet Receptor Inhibition for Ischemic Syndrome Management), PRISM-PLUS (Platelet Receptor Inhibition for Ischemic Syndrome Management — Patients Limited by Unstable Signs and Symptoms) and RESTORE (Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis) trials, 1946 patients received Tirofiban in combination with heparin and 2002 patients received Tirofiban alone for about 3 days. Forty-three percent of the population was greater than 65 years of age and approximately 30% of patients were female. In clinical studies with the recommended regimen (25 mcg/kg bolus followed by a 0.15 mcg/kg/min maintenance infusion), Tirofiban was administered in combination with aspirin, clopidogrel and heparin or bivalirudin to over 8000 patients for typically ≤24 hours. Approximately 30% of the population was >65 years of age and approximately 25% were female.

Bleeding

PRISM-PLUS Regimen

The incidences of major and minor bleeding using the TIMI criteria in the PRISM-PLUS study are shown below.

Postmarketing Experience

The following additional adverse reactions have been identified during post-approval use of Tirofiban. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to the drug exposure.

Hypersensitivity: Severe allergic reactions including anaphylactic reactions have occurred during the first day of Tirofiban infusion, during initial treatment, and during readministration of Tirofiban. Some cases have been associated with severe thrombocytopenia (platelet counts less than 10,000/mm3). No information is available on the formation of antibodies to tirofiban.

Drug Interactions

Use ofthrombolytics, anticoagulants, and other antiplatelet agents.

Coadministration of antiplatelet agents, thrombolytics, heparin, and aspirin increases the risk of bleeding.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): BThere are no adequate and well-controlled studies in pregnant women. Tirofiban has been shown to cross the placenta in pregnant rats and rabbits. Studies with tirofiban HCl at intravenous doses up to 5 mg/kg/day (about 5 and 13 times the maximum recommended daily human dose for rat and rabbit, respectively, when compared on a body surface area basis) have revealed no harm to the fetus.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Tirofiban in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Tirofiban during labor and delivery.

Nursing Mothers

It is not known whether tirofiban is excreted in human milk. However, significant levels of tirofiban were shown to be present in rat milk. Because many drugs are excreted in human milk, and because of the potential for adverse effects on the nursing infant, discontinue nursing or discontinue Tirofiban.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatic Use

Of the total number of patients in controlled clinical studies of Tirofiban, 43% were 65 years and over, while 12% were 75 and over. With respect to efficacy, the effect of Tirofiban in the elderly (≥65 years) appeared similar to that seen in younger patients (less than 65 years). Elderly patients receiving Tirofiban with heparin or heparin alone had a higher incidence of bleeding complications than did younger patients, but the incremental risk of bleeding in patients treated with Tirofiban in combination with heparin compared to the risk in patients treated withheparin alone was similar regardless of age. No dose adjustment is recommended for the elderly population .

Gender

There is no FDA guidance on the use of Tirofiban with respect to specific gender populations.

Race

There is no FDA guidance on the use of Tirofiban with respect to specific racial populations.

Renal Impairment

Patients with moderate to severerenal insufficiency have decreased plasma clearance of Tirofiban. Reduce the dosage of Tirofiban in patients with severe renal insufficiency .

Safety and efficacy of Tirofiban has not been established in patients on hemodialysis.

Hepatic Impairment

There is no FDA guidance on the use of Tirofiban in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Tirofiban in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Tirofiban in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Tirofiban Administration in the drug label.

Monitoring

There is limited information regarding Tirofiban Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Tirofiban and IV administrations.

Overdosage

In clinical trials, inadvertent overdosage with Tirofiban occurred in doses up to 2 times the recommended dose for initial infusion doses. Inadvertent overdosage occurred in doses up to 9.8 times the 0.15 mcg/kg/min maintenance infusion rate.

The most frequently reported manifestation of overdosage was bleeding, primarily minor mucocutaneous bleeding events and minor bleeding at the sites of cardiac catheterization .

Overdosage of Tirofiban should be treated by assessment of the patient's clinical condition and cessation or adjustment of the drug infusion as appropriate.

Tirofiban can be removed by hemodialysis.

Pharmacology

Mechanism of Action

Tirofiban is a reversible antagonist of fibrinogen binding to the GP IIb/IIIa receptor, the major platelet surface receptor involved in platelet aggregation. When administered intravenously, Tirofiban inhibits ex vivo platelet aggregation in a dose- and concentration-dependent manner.

When given according to the PRISM-PLUS regimen of 0.4 mcg/kg/min for 30 minutes followed by a 0.1 mcg/kg/min maintenance infusion, greater than 90% inhibition of platelet aggregation is attained by the end of the 30-minute infusion. When given according to the recommended regimen of 25 mcg/kg over 3 min followed by a 0.15 mcg/kg/min maintenance infusion, greater than 90% inhibition of platelet aggregation is attained within 10 minutes. Platelet aggregation inhibition is reversible following cessation of the infusion of Tirofiban.

Structure

Tirofiban contains tirofiban hydrochloride, a non-peptide antagonist of the platelet GP IIb/IIIa receptor, inhibits platelet aggregation.

Tirofiban hydrochloride monohydrate is chemically described as N(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine monohydrochloride monohydrate.

Its molecular formula is C22H36N2O5S•HCl•H2O and its structural formula is:

Tirofiban hydrochloride monohydrate is a white to off-white, non-hygroscopic, free-flowing powder, with a molecular weight of 495.08. It is very slightly soluble in water.

Tirofiban Injection Premixed is supplied as a sterile solution in water for injection, for intravenous use only, in plastic containers of 100 mL or 250 mL. Each 100 mL of the premixed, iso-osmotic intravenous injection contains 5.618 mg tirofiban hydrochloride monohydrate equivalent to 5 mg tirofiban (50 mcg/mL) and the following inactive ingredients: 0.9 g sodium chloride, 54 mg sodium citrate dihydrate, and 3.2 mg citric acid anhydrous. Each 250 mL of the premixed, iso-osmotic intravenous injection contains 14.045 mg tirofiban hydrochloride monohydrate equivalent to 12.5 mg tirofiban (50 mcg/mL) and the following inactive ingredients: 2.25 g sodium chloride, 135 mg sodium citrate dihydrate, and 8 mg citric acid anhydrous.

The pH of the solution ranges from 5.5 to 6.5 and may have been adjusted with hydrochloric acid and/or sodium hydroxide. The flexible container is manufactured from a specially designed multilayer plastic (PL 2408). Solutions in contact with the plastic container leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.

Pharmacodynamics

Tirofiban inhibits platelet function, as demonstrated by its ability to inhibit ex vivo adenosine phosphate (ADP)-induced platelet aggregation and prolong bleeding time in healthy subjects and patients with coronary artery disease. The time course of inhibition parallels the plasma concentration profile of the drug.

Following discontinuation of an infusion of Tirofiban 0.10 mcg/kg/min, ex vivo platelet aggregation returns to near baseline in 4 to 8 hours in approximately 90% of patients with coronary artery disease. The addition of heparin to this regimen does not significantly alter the percentage of subjects with >70% inhibition of platelet aggregation (IPA), but does increase the average bleeding time, as well as the number of patients with bleeding times prolonged to >30 minutes. Similar platelet aggregation recovery rates are observed following discontinuation of a 0.15 mcg/kg/min infusion.

Pharmacokinetics

Tirofiban has a half-life of approximately 2 hours. It is cleared from the plasma largely by renal excretion, with about 65% of an administered dose appearing in urine and about 25% in feces, both largely as unchanged tirofiban. Metabolism appears to be limited.

Tirofiban is not highly bound to plasma proteins and protein binding is concentration independent over the range of 0.01 to 25 mcg/mL. The unbound fraction in human plasma is 35%. The steady state volume of distribution of tirofiban ranges from 22 to 42 liters.

In healthy subjects, the plasma clearance of tirofiban ranges from 213 to 314 mL/min. Renal clearance accounts for 39 to 69% of plasma clearance.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

The carcinogenic potential of Tirofiban has not been evaluated.

Tirofiban HCI was negative in the in vitro microbial mutagenesis and V-79 mammalian cell mutagenesis assays. In addition, there was no evidence of direct genotoxicity in the in vitro alkaline elution and in vitro chromosomal aberration assays. There was no induction of chromosomal aberrations in bone marrow cells of male mice after the administration of intravenous doses up to 5 mg tirofiban/kg (about 3 times the maximum recommended daily human dose when compared on a body surface area basis).

Fertility and reproductive performance were not affected in studies with male and female rats given intravenous doses of tirofiban up to 5 mg/kg/day (about 5 times the maximum recommended daily human dose when compared on a body surface area basis).

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Clinical Studies

Two large-scale clinical studies established the efficacy of Tirofiban in the treatment of patients with NSTE-ACS (unstable angina/]non-ST elevation MI). The two studies examined Tirofiban alone and added to heparin, prior to and after percutaneous coronary revascularization (if indicated) (PRISM-PLUS) and in comparison to heparin in a similar population (PRISM). These trials are discussed in detail below.

PRISM-PLUS (Platelet Receptor Inhibition for Ischemic Syndrome Management — Patients Limited by Unstable Signs and Symptoms)

In the double-blind PRISM-PLUS trial, 1570 patients with documented NSTE-ACS within 12 hours of entry into the study were randomized to Tirofiban (30 minute initial infusion of 0.4 mcg/kg/min followed by a maintenance infusion of 0.10 mcg/kg /min) in combination with heparin (bolus of 5,000 U followed by an infusion of 1,000 U/h titrated to maintain an APTT of approximately 2 times control) or to heparin alone. All patients received concomitant aspirin unless contraindicated. Patients who were medically managed or who underwent revascularization procedures were studied. Patients underwent 48 hours of medical stabilization on study drug therapy, and they were to undergo angiography before 96 hours (and, if indicated, angioplasty/atherectomy, while continuing on Tirofiban and heparin for 12-24 hours after the procedure). Tirofiban and heparin could be continued for up to 108 hours.

Exclusions included contraindications to anticoagulation, decompensated heart failure, platelet count <150,000/mm3, and serum creatinine >2.5 mg/dL. The mean age of the population was 63 years; 32% of patients were female and approximately half of the population presented with non-ST elevation myocardial infarction. On average, patients received Tirofiban for 71 hours.

A third group of patients was initially randomized to Tirofiban alone (no heparin). This arm was stopped when the group was found, at an interim look, to have greater mortality than the other two groups.

The primary endpoint of the study was a composite of refractory ischemia, new MI and death within 7 days. There was a 32% risk reduction in the overall composite primary endpoint. The components of the composite were examined separately and the results are shown in Table 5. Note that the sum of the individual components may be greater than the composite (if a patient experiences multiple component events only one event counts towards the composite).

The benefit seen at 7 days was maintained over time. The risk reduction in the composite endpoint at 30 days and 6 months is shown in the Kaplan-Meier curve below.

An analysis of the results by sex suggests that women who are medically managed or who undergo subsequent PTCA/atherectomy may receive less benefit from Tirofiban (95% confidence limits for relative risk of 0.61-1.74) than do men (0.43-0.89) (p=0.11). This difference may be a true treatment difference, the effect of other differences in these subgroups, or a chance occurrence.

Approximately 90% of patients in the PRISM-PLUS study underwent coronary angiography and 30% underwent angioplasty/atherectomy during the first 30 days of the study. The majority of these patients continued on study drug throughout these procedures. Tirofiban was continued for 12-24 hours (average 15 hours) after angioplasty/atherectomy. The effects of Tirofiban at Day 30 did not appear to differ among sub-populations that did or did not receive PTCA or CABG, both prior to and after the procedure.

PRISM (Platelet Receptor Inhibition for Ischemic Syndrome Management)

In the PRISM study, a randomized, parallel, double-blind study, 3232 patients with NSTE-ACS intended to be managed without coronary intervention were randomized to Tirofiban (initial dose of 0.6 mcg/kg/min for 30 minutes followed by 0.15 mcg/kg/min for 47.5 hours) or heparin (5000-unit intravenous bolus followed by an infusion of 1000 U/h for 48 hours). The mean age of the population was 62 years; 32% of the population was female and 25% had non-ST elevation MI on presentation. Thirty percent had no ECG evidence of cardiac ischemia. Exclusion criteria were similar to PRISM-PLUS. The primary endpoint was the composite endpoint of refractory ischemia, MI or death at the end of the 48-hour drug infusion. The results are shown in Table 6.

In the PRISM study, no adverse effect of Tirofiban on mortality at either 7 or 30 days was detected. This result is different from that in the PRISM-PLUS study, where the arm that included Tirofiban without heparin (n=345) was dropped at an interim analysis by the Data Safety Monitoring Committee for increased mortality at 7 days.

How Supplied

There is limited information regarding Tirofiban How Supplied in the drug label.

Storage

There is limited information regarding Tirofiban Storage in the drug label.

Images

Drug Images

Package and Label Display Panel

Patient Counseling Information

Advise patients to watch closely for any signs of bleeding or bruising and to report these to their health care provider when they occur.

Advise patients to discuss with their health care provider their use of any other medications, including over-the-counter or herbal products prior to Tirofiban use.

Patent: www.medicure.com/Tirofiban/patents

Tirofiban is manufactured for:

MEDICURE INTERNATIONAL, INC.

by:

BAXTER HEALTHCARE CORPORATION

Deerfield, Illinois 60015 USA

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Distributed by:

MEDICURE PHARMA, INC.Somerset, NJ 08873 USA1-800-509-0544Printed in USA07-19-72-370

• Registered trademark of Medicure International Inc.

© 2013 Copyright used under license.All rights reserved.Intravia is a registered trademark of Baxter International Inc.alcohol=Alcohol-Tirofiban sandbox interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Precautions with Alcohol

Alcohol-Tirofiban interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.

Brand Names

AGGRASTAT

Look-Alike Drug Names

Tirofiban - argatroban ^[1]

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine. Disk mounter 1 1.

1. ↑'https://www.ismp.org'.External link in |title= (help)

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